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Moreover, we observed that the expression of CD133, a cancer stem cell marker 35 , was also increased in ES2, OVCAR8 and A2780 parental cells but not in OVCAR3 cells, upon cyclic exposure to hypoxia

Besides cancer heterogenicity and specificity, some other issues still exist in cancer treatment by ACPs

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When injected into a monkey model of endometriosis with its long-acting recovery antibody (AMY109), IL-8, a potent chemoattractant for angiogenic factors and immune cells, can inhibit neutrophil recruitment to endometrial lesions and suppress their production of monocyte chemotactic protein-1, thereby ameliorating endometriosis inflammation and fibrosis (59)